Lorazepam (Ativan)

Indications

Intensive Care Unit Sedation (see Sedation, [[Sedation]])

  • Need for Sedation While on Mechanical Ventilation

Intoxication/Withdrawal

  • Ethanol Withdrawal (see Ethanol, [[Ethanol]])

Procedural Sedation (see Sedation, [[Sedation]])

  • Bone Marrow Biopsy (see Bone Marrow Biopsy, [[Bone Marrow Biopsy]])
  • Bronchoscopy (see Bronchoscopy, [[Bronchoscopy]])
  • Cardioversion for Atrial Fibrillation (see Atrial Fibrillation, [[Atrial Fibrillation]])
  • Dental Procedures
  • Endoscopy
  • Fine Needle Aspiration (FNA) of Mass/Lesion
  • Foreign Body Extraction: particularly in pediatric populations
  • Surgery

Other


Pharmacology


Administration

  • PO: 0.5-1 mg PRN
  • IV: 0.5-1 mg PRN

Dose Adjustment

  • Hepatic
  • Renal

Adverse Effects

Cardiovascular Adverse Effects

Hypotension (see Hypotension, [[Hypotension]])

  • xxx

Gastrointestinal Adverse Effects

Increased Risk of Hepatic Encephalopathy (see Hepatic Encephalopathy, [[Hepatic Encephalopathy]])

  • xxx

Pulmonary Adverse Effects

Respiratory Depression

Toxicologic Adverse Effects

Propylene Glycol Intoxication (see Propylene Glycol, [[Propylene Glycol]])

  • Epidemiology: associated with continuous intravenous administration

Other Adverse Effects

  • xxx
  • xxx
  • xxx

References

  • xxx