Epithelial Sodium Channel Antagonists (ENaC Antagonists)

Agents

  • Amiloride (Midamor) (see Amiloride, [[Amiloride]])
  • Cimetidine (Tagamet) (see Cimetidine, [[Cimetidine]])
  • Nafamostat: synthetic serine protease inhibitor, used as an anticoagulant
  • Pentamidine (Nebupent) (see Pentamidine, [[Pentamidine]])
  • Triamterene (Dyrenium, Dyazide, Maxzide) (see Triamterene, [[Triamterene]])
  • Trimethoprim (see Sulfamethoxazole-Trimethoprim, [[Sulfamethoxazole-Trimethoprim]])

Pharmacology

  • Inhibit Sodium Channels on the Luminal Membrane of Cells in the Renal Collecting Tubule: the collecting tubule is the site of action of aldosterone

References

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