Cimetidine (Tagamet)

Indications


Pharmacology

  • H2-Histamine Receptor Antagonist (see H2-Histamine Receptor Antagonists, [[H2-Histamine Receptor Antagonists]]
  • Epithelial Sodium Channel (ENaC) Antagonist (see Epithelial Sodium Channel Antagonists, [[Epithelial Sodium Channel Antagonists]]): acts to close sodium channels on the luminal membrane of cells in the collecting tubule (collecting tubule is the site of action of aldosterone)

Metabolism

  • xxxx

Administration

  • PO:
  • IV:

Dose Adjustment

  • Hepatic: xxx
  • Renal: xxx

Adverse Effects

Gastrointestinal Adverse Effects

  • Acute Pancreatitis (see Acute Pancreatitis, [[Acute Pancreatitis]])
    • Epidemiology: probable association

Other Adverse Effects

  • xxxx
  • xxxx
  • xxxx
  • xxxx

References

  • xxx