Bendamustine (Treakisym, Ribomustin, Levact, Treanda, SDX-105)

Indications


Pharmacology

  • Nitrosourea (see Nitrosoureas, [[Nitrosoureas]])
    • Alkylating Agent

Administration

  • IV

Adverse Effects

Pulmonary Adverse Effects

  • Dyspnea (see Dyspnea, [[Dyspnea]]): isolated dyspnea occurred in 12% of cases in treatment of small cell lung cancer [MEDLINE]
  • Increased Risk of Pneumocystis Jirovecii Pneumonia (see Pneumocystis Jirovecii, [[Pneumocystis Jirovecii]]): case report

Other Adverse Effects

  • xxxx
  • xxxx
  • xxxx
  • xxxx

References

  • Pneumocystis carinii pneumonia as a complication of bendamustine monotherapy in a patient with advanced progressive breast cancer. J Cancer Res Clin Oncol. 2003 May;129(5):316-9. Epub 2003 May 17 [MEDLINE]
  • Phase II study of bendamustine in relapsed chemotherapy sensitive or resistant small-cell lung cancer. J Thorac Oncol. 2014 Apr;9(4):559-62. doi: 10.1097/JTO.0000000000000079 [MEDLINE]