Multiple Myeloma

Epidemiology

  • aka Plasmacytoma

Physiology

  • xxx

Pathology

  • Pathologic Patterns
    • Amyloid deposition: in lung

Clinical Manifestations

Hematologic Manifestations

Rheumatologic/Orthopedic Manifestations

  • Bone Lesions: ribs, clavicles, scapulae
  • Metastatic Calcification (see Metastatic Calcification, [[Metastatic Calcification]])

Pulmonary Manifestations

  • Single or Multiple Lung Nodules or Masses (see [[Lung Nodule or Mass]])
    • Solitary Plasmacytoma: lobulated nodule with no lobar predilection, calcification, or cavitation
  • Pneumonia-Like Infiltrate (see Pneumonia, [[Pneumonia]]): lobar or segmental infiltrate
  • Interstitial Infiltrates (see Interstitial Lung Disease-Etiology, [[Interstitial Lung Disease-Etiology]]): rare presentation [J Clin Onc 2010; 28]
  • Pleural Effusion (see Pleural Effusion-Exudate, [[Pleural Effusion-Exudate]])

Renal Manifestations

  • Acute Kidney Injury (AKI) (see Acute Kidney Injury, [[Acute Kidney Injury]]): due to intratubular deposition and obstruction

Treatment

  • xxx

References

  • xxx