Nitrosoureas

Agents

  • Bendamustine (Treakisym, Ribomustin, Levact, Treanda, SDX-105) (see Bendamustine, [[Bendamustine]])
  • Carmustine (BCNU) (see Carmustine, [[Carmustine]])
  • Chlorozotocin (see Chlorozotocin, [[Chlorozotocin]])
  • Ethylnitrosourea (ENU)
  • Fotemustine (see Fotemustine, [[Fotemustine]])
  • Lomustine (CCNU) (see Lomustine, [[Lomustine]])
  • Semustine (methyl-CCNU) (see Semustine, [[Semustine]])
  • Streptozotocin

Pharmacology

  • DNA Alkylating Agents: attaches an alkyl group (CnH2n+1) to guanine base of DNA, at the number 7 nitrogen atom of the purine ring
  • Lipophilic : able to cross the blood-brain barrier

References

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