Pregabalin (Lyrica)
Indications
Chronic Refractory Cough (see Cough , [[Cough]])
Clinical Efficacy
Trial of Speech Therapy and Pregabalin in Patients with Unexplained Chronic Refractory Cough (Chest, 2016) [MEDLINE ]
Speech Therapy Combined with Pregabalin Decreased Symptoms and Improved Quality of Life, Compared with Speech Therapy Alone in Patients with Unexplained Chronic Refractory Cough
Fibromyalgia (see Fibromyalgia , [[Fibromyalgia]])
Generalized Anxiety Disorder (see Anxiety , [[Anxiety]])
Neuropathic Pain
Partial Seizures (see Seizures , [[Seizures]])
Restless Legs Syndrome (RLS) (see Restless Legs Syndrome , [[Restless Legs Syndrome]])
Pharmacology
Metabolism
Administration
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Gradual tapering of pregabalin is recommended when the drug is withdrawn
Dose Adjustment
Adverse Effects
Cardiovascular Adverse Effects
Hypertension (see Hypertension , [[Hypertension]]): occurs in <0.1% of patients
Hypotension (see Hypotension , [[Hypotension]]): occurs in <0.1% of patients
Tachycardia (see Sinus Tachycardia , [[Sinus Tachycardia]]: occurs in 0.1–1% of patients
Endocrinologic Adverse Effects
Hypoglycemia (see Hypoglycemia , [[Hypoglycemia]]: occurs in 0.1–1% of patients
Weight Gain (see Weight Gain , [[Weight Gain]]): occurs in 1-10% of cases
Pharmacology : due to increased appetite
Gastrointestinal Adverse Effects
Hematology Adverse Effects
Neutropenia (see Neutropenia , [[Neutropenia]]): occurs in <0.1% of patients
Thrombocytopenia (see Thrombocytopenia , [[Thrombocytopenia]]: occurs in 0.1–1% of patients
Neurologic Adverse Effects
Ataxia (see Ataxia , [[Ataxia]]): occurs in 1-10% of cases
Blurred Vision/Diplopia : occurs in 1-10% of cases
Delirium/Confusion (see Delirium , [[Delirium]]): occurs in 1-10% of cases
Discoordination : occurs in 1-10% of cases
Dizziness (see Dizziness , [[Dizziness]]): occurs in >10% of cases
Drowsiness : occurs in >10% of cases
Dysarthria (see Dysarthria , [[Dysarthria]]): occurs in 1-10% of cases
Euphoria : occurs in 1-10% of cases
Increased/Decreased Libido : occurs in 1-10% of cases
Irritability : occurs in 1-10% of cases
Myoclonus (see Myoclonus , [[Myoclonus]]: occurs in 0.1–1% of patients
Parasthesias (see Parasthesias , [[Parasthesias]]): occurs in 1-10% of cases
Tremor (see Tremor , [[Tremor]]): occurs in 1-10% of cases
Vivid Dreams : occurs in 1-10% of cases
Other Adverse Effects
Dry Mouth : occurs in 1-10% of cases
Flushing (see Flushing , [[Flushing]]: occurs in 0.1–1% of patients
Nasopharyngitis (see Pharyngitis , [[Pharyngitis]]): occurs in 1-10% of cases
Peripheral Edema (see Peripheral Edema , [[Peripheral Edema]]): occurs in 1-10% of cases
Rhabdomyolysis (see Rhabdomyolysis , [[Rhabdomyolysis]]): occurs in <0.1% of patients
Increased creatine kinase occurs in 1-10% of cases
Pregabalin Withdrawal
Neurologic Manifestations
Gastrointestinal Manifestations
Other Manifestations
References
Pregabalin and Speech Pathology Combination Therapy for Refractory Chronic Cough: A Randomized Controlled Trial. Chest. 2016;149(3):639 [MEDLINE ]
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