Epithelial Sodium Channel (ENaC) Antagonist (see Epithelial Sodium Channel Antagonists, [[Epithelial Sodium Channel Antagonists]]): inhibits sodium channels on the luminal membrane of cells in the renal collecting tubule
Collecting tubule is the site of action of aldosterone
Administration
INH (Prophylaxis)
IV (Treatment)
Dose Adjustment
Hepatic
Renal
Adverse Effects
Cardiovascular Adverse Effects
Q-T Prolongation with Definite Association with Torsade (see Torsade, [[Torsade]])