Antipsychotic Agents


Agents

First-Generation Antipsychotic Agents (see Antipsychotic Agents)

  • General Comments
    • First-Generation Antipsychotic Agents Have a Higher Incidence of Extrapyramidal Adverse Effects and Tardive Dyskinesia, as Compared to the Second-Generation Antipsychotic Agents
  • Low-Potency Agents: higher anticholinergic side effects, lower extrapyramidal side effects
  • High-Potency Agents: lower anticholinergic side effects, higher extrapyramidal side effects

Second-Generation Antipsychotic Agents (Atypical Antipsychotics) (see Antipsychotic Agents)

  • General Comments
    • Second-Generation Antipsychotic Agents are Generally Believed to Have a Lower Incidence of Extrapyramidal Adverse Effects and Tardive Dyskinesia, as Compared to the First-Generation Antipsychotic Agents: likely related to the weaker affinity of these agents for the dopamine D2 receptor
    • However, Other Studies Have Suggested that the Differences Between First and Second-Generation Antipsychotics with Regard to Extrapyramidal Side Effects May Be More Minimal than Has Been Previously Believed (Lancet, 2003) [MEDLINE]
  • Aripiprazole (Abilify) (see Aripiprazole)
  • Asenapine (see Asenapine)
  • Brexpiprazole (Rexulti) (see Brexpiprazole)
  • Cariprazine (see Cariprazine)
  • Clozapine (Clozaril) (see Clozapine)
    • Epidemiology
      • Clozapine Has a Low Risk of Acute Extrapyramidal Effects, as Well as a Rare Association with Tardive Dyskinesia
  • Iloperidone (Fanapt, Zomaril) (see Iloperidone)
  • Lurasidone (Latuda) (see Lurasidone)
  • Olanzapine (Zyprexa) (see Olanzapine)
    • Epidemiology
      • Highest Risk of Tardive Dyskinesia Among the Second-Generation Antipsychotics
  • Paliperidone (Invega) (see Paliperidone)
  • Pimavanserin (Nuplazid) (see Pimavanserin)
  • Quetiapine (Seroquel) (see Quetiapine)
  • Risperidone (Risperdal) (see Risperidone)
    • Epidemiology
      • Highest Risk of Tardive Dyskinesia Among the Second-Generation Antipsychotics
  • Ziprasidone (Geodon) (see Ziprasidone)


References