Etiology of Elevated Serum Immunoglobulin E

Atopic Disease

• Allergic Bronchopulmonary Aspergillosis (ABPA) (see Allergic Bronchopulmonary Aspergillosis, [[Allergic Bronchopulmonary Aspergillosis]]): see below
• Allergic Fungal Sinusitis
• Allergic Rhinitis (see Allergic Rhinitis, [[Allergic Rhinitis]])
• Asthma (see Asthma, [[Asthma]]): see below
• Atopic Dermatitis (see Atopic Dermatitis, [[Atopic Dermatitis]])

Immunodeficiency

• Atypical Complete DiGeorge Syndrome
• Hyper IgE-Recurrent Infection Syndrome (Job’s Syndrome, Buckley-Job Syndrome) (see Hyper IgE-Recurrent Infection Syndrome, [[Hyper IgE-Recurrent Infection Syndrome]])
• Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome (IPEX)
• Netherton Disease
• Omenn Syndrome
• Wiskott-Aldrich Syndrome

Infectious Disease

• Viral
  • Cytomegalovirus (CMV) (see Cytomegalovirus, [[Cytomegalovirus]])
  • Epstein-Barr Virus (EBV) (see Epstein-Barr Virus, [[Epstein-Barr Virus]])
  • Human Immunodeficiency Virus (HIV) (see Human Immunodeficiency Virus, [[Human Immunodeficiency Virus]])
• Bacterial
  • Tuberculosis (see Tuberculosis, [[Tuberculosis]])
• Fungal
  • Candida (see Candida, [[Candida]])
• Parasitic
  • Ascariasis (see Ascariasis, [[Ascariasis]])
  • Schistosomiasis (see Schistosomiasis, [[Schistosomiasis]])
  • Strongyloidiasis (see Strongyloidiasis, [[Strongyloidiasis]])
  • Tropical Pulmonary Eosinophilia (see Tropical Pulmonary Eosinophilia, [[Tropical Pulmonary Eosinophilia]]): serum IgE usually >10,000 ng/mL (4200 IU/mL)
    • Wuchereria Bancrofti
    • Brugia Malayi
    • Brugia Timori

Inflammatory Disease

• Churg-Strauss Syndrome (Eosinophilic Granulomatosis with Polyangiitis) (see Churg-Strauss Syndrome, [[Churg-Strauss Syndrome]])
• Kimura Disease

Neoplastic Disease

• Hodgkin’s Disease (see Hodgkin’s Disease, [[Hodgkins Disease]])
• IgE Myeloma (see Multiple Myeloma, [[Multiple Myeloma]])

Pulmonary Disease

• Allergic Bronchopulmonary Aspergillosis (ABPA) (see Allergic Bronchopulmonary Aspergillosis, [[Allergic Bronchopulmonary Aspergillosis]])
  • Elevated: >1000 IU/mL (International Society for Human and Animal Mycology, ISHAM) (Clin Exp Allergy, 2013) [MEDLINE]
    • Generally Higher in ABPA than in Asthma
    • May Be as High as 25k IU/mL
    • Serum IgE May Decrease (But Does Not Usually Normalize) Following Glucocorticoid Administration
• Asthma (see Asthma, [[Asthma]])
  • Epidemiology:
  • Clinical: xxx
• Cystic Fibrosis (CF) (see Cystic Fibrosis, [[Cystic Fibrosis]])
  • Epidemiology: IgE is elevated in 22% of cases
  • Clinical: xxx

Other

• Bullous Pemphigoid (see Bullous Pemphigoid, [[Bullous Pemphigoid]])
• Hematopoietic Stem Cell Transplant (HSCT) (see Hematopoietic Stem Cell Transplant, [[Hematopoietic Stem Cell Transplant]])
• Nephrotic Syndrome (see Nephrotic Syndrome, [[Nephrotic Syndrome]])
• Tobacco Abuse (see Tobacco, [[Tobacco]])

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References

• Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. Clin Exp Allergy. 2013;43(8):850 [MEDLINE]