Piroxicam (Feldene)
Indications
- Arthritis
- Dysmenorrhea (see Dysmenorrhea)
- Fever (see Fever)
- Pain
- Post-Operative Pain
- Soft Tissue/Musculoskeletal Injury
- To Decrease the Risk of Malignancy
Contraindications
Pharmacology
Metabolism
Administration
Dose Adjustment
Use in Pregnancy (see xxxx)
Use During Breast Feeding
Adverse Effects
Endocrinologic Adverse Effects
Drug-Induced Hyporeninemic Hypoaldosteronism (see Hypoaldosteronism)
- Physiology
- Class Effect, Common to All NSAID’s
- Dose-Dependent COX-Inhibition, Resulting in Decreased Renal Prostaglandin Synthesis and Therefore, Drug-Induced Hyporeninemic Hypoaldosteronism
- Clinical
Gastrointestinal Adverse Effects
- Physiology
- Class Effect, Common to All NSAID’s
Pulmonary Adverse Effects
Aspirin-Intolerant Asthma (see Asthma)
- Physiology
- Class Effect, Common to All NSAID’s
- Associated Agents
- Acetylsalicylic Acid (Aspirin) (see Acetylsalicylic Acid)
- Diclofenac (Aclonac, Cataflam, Voltaren) (see Diclofenac)
- Diflunisal (Dolobid)
- Fenbufen
- Fenoprofen (see Fenoprofen): case reports
- Ibuprofen (Advil, Brufen, Motrin, Nurofen) (see Ibuprofen): case reports
- Indomethacin (Indocin) (see Indomethacin)
- Loxoprofen
- Meloxicam (see Meloxicam)
- Naproxen (Naprosyn, Aleve) (see Naproxen): appears to be more frequent with naproxen than other NSAID’s
- Nimesulide
- Phenylbutazone
- Piroxicam (Feldene) (see Piroxicam)
- Pranoprofen
- Sulindac (Clinoril) (see Sulindac): case reports
- Tenidap
- Tiaprofenic Acid
- Tolfenamic Acid
- Diagnosis
- Lung Biopsy: poorly defined granulomas with infiltrating eosinophils
- Clinical
- Cough
- Dyspnea
- Fever
- Peripheral Eosinophilia
- Pulmonary Infiltrates
Renal Adverse Effects
- Physiology
- Class Effect, Common to All NSAID’s
- Mechanism
- Due to NSAID-Induced Hyporeninemic Hypoaldosteronism
Increased Renal Sodium Reabsorption with Peripheral Edema
- Risk Factors
- Physiology
- Decreased PGE2, Resulting in Increased Renal Sodium Reabsorption
- Class Effect, Common to All NSAID’s
- Dose-Dependent Effect
- Clinical
- Physiology
- Due to NSAID-Induced Hyporeninemic Hypoaldosteronism
- Clinical
Other Adverse Effects
References