Phosphodiesterase Type 4 Inhibitors (PDE4 Inhibitors)

Agents

  • Apremilast (Otezla) (see Apremilast, [[Apremilast]])
  • Drotaverine
  • Ibudilast
  • Luteolin
  • Mesembrine
  • Piclamilast
  • Roflumilast (Daliresp, Daxas) (see Roflumilast, [[Roflumilast]])
  • Rolipram

Pharmacology

  • Phosphodiesterase Type 4 is the Predominant cAMP-Metabolizing Enzyme Found in Inflammatory/Immune Cells: this explains the anti-inflammatory properties of these agents

References

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