Norepinephrine (Levophed)

Indications


Pharmacology

  • α1-Adrenergic Receptor Agonist (see α1-Adrenergic Receptor Agonists, [[α1-Adrenergic Receptor Agonists]])
  • β1-Adrenergic Receptor Agonist (see β1-Adrenergic Receptor Agonists, [[β1-Adrenergic Receptor Agonists]])
    • Positive Chronotropy with Increase in Blood Pressure) -> increased cardiac output
    • Positive Inotropy (with Increase in Blood Pressure) -> increased cardiac output
  • β2-Adrenergic Receptor Agonist (see β2-Adrenergic Receptor Agonists, [[β2-Adrenergic Receptor Agonists]])
    • Bronchodilation
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Metabolism

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Administration

  • IV: 2-30 ug/min

Dose Adjustment

  • Hepatic:
  • Renal:

Risk of Extravasation-Associated Tissue Damage

  • Tissue Necrosis

Adverse Effects

Cardiovascular Adverse Effects

  • Arrhythmias
  • Exacerbation of Myocardial Ischemia (see Coronary Artery Disease, [[Coronary Artery Disease]])
  • Hypertension (see Hypertension, [[Hypertension]]): especially in patients on non-selective beta blockers
  • QT Prolongation without Definite Association with Torsade (see Torsade, [[Torsade]])
  • Sinus Tachycardia (see Sinus Tachycardia, [[Sinus Tachycardia]])

Other Adverse Effects

  • Digital Ischemia
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References

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