Naloxone (Narcan)

Indications

  • Ileus (see Ileus, [[Ileus]])
  • Opiate Intoxication (see Opiates, [[Opiates]])

Pharmacology

  • Opiate Receptor Antagonist
    • Reversal of respiratory depression by partial agonists or mixed agonists/antagonists (pentazocine, buprenorphine) may be incomplete

Administration

  • PO (treatment of ileus):
  • IV (treatment of opiate intoxication): 1 amp (0.4 mg) PRN
  • Evzio SQ/IV Auto-Injector (treatment of opiate Intoxication): 0.4 mg single-use injector that may be administered by family member or caregiver

Adverse Effects

Cardiovascular Adverse Effects

  • Cardiac Arrest (see Cardiac Arrest, [[Cardiac Arrest]]): may occur with post-op naloxone administration
  • Hypertension (see Hypertension, [[Hypertension]]): may occur with post-op naloxone administration
  • Hypotension (see Hypotension, [[Hypotension]]): may occur with post-op naloxone administration
  • Ventricular Fibrillation (see Ventricular Fibrillation, [[Ventricular Fibrillation]]): may occur with post-op naloxone administration
  • Ventricular Tachycardia (see Ventricular Tachycardia, [[Ventricular Tachycardia]]): may occur with post-op naloxone administration

Neurologic Adverse Effects

  • Agitation: may occur with post-op naloxone administration

Pulmonary Adverse Effects

Other Adverse Effects

  • Opiate Withdrawal (see Opiates, [[Opiates]]): in patients with opiate dependence

References

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