Cephalosporins

Pharmacology

  • Semi-Synthetic Beta-Lactam Antibiotics (see β-Lactam Antibiotics, [[β-Lactam Antibiotics]]): derived from Cephalosporium mold
    • Inhibition of bacterial cell synthesis (similar to penicillins)

Agents

First Generation

  • Cefadroxil (Duricef) (see Cefadroxil, [[Cefadroxil]])
  • Cefazolin (Ancef, Kefzol) (see Cefazolin, [[Cefazolin]])
  • Cephalexin (Keflex) (see Cephalexin, [[Cephalexin]])
  • Cephradrine (Velosef) (see Cephradrine, [[Cephradrine]])

Second Generation

  • Cefaclor (Ceclor, Raniclor) (see Cefaclor, [[Cefaclor]])
  • Cefotetan (Cefotan) (see Cefotetan, [[Cefotetan]])
  • Cefotiam (see Cefotiam, [[Cefotiam]])
  • Cefoxitin (Mefoxin) (see Cefoxitin, [[Cefoxitin]])
  • Cefprozil (Cefzil) (see Cefprozil, [[Cefprozil]])
  • Cefuroxime (Zinacef, Ceftin) (see Cefuroxime, [[Cefuroxime]])
  • Loracarbef (Lorabid) (see Loracarbef, [[Loracarbef]])

Third Generation

  • Cefdinir (Omnicef) (see Cefdinir, [[Cefdinir]])
  • Cefditoren (Sprectacef) (see Cefditoren, [[Cefditoren]])
  • Cefixime (Suprax) (see Cefixime, [[Cefixime]])
  • Cefoperazone (Cefobid) (see Cefoperazone, [[Cefoperazone]])
  • Cefotaxime (Claforan) (see Cefotaxime, [[Cefotaxime]])
  • Cefpodoxime (Vantin) (see Cefpodoxime, [[Cefpodoxime]])
  • Ceftazidime (Fortaz, Tazicef, Ceptaz) (see Ceftazidime, [[Ceftazidime]])
  • Ceftibuten (Cedax) (see Ceftibuten, [[Ceftibuten]])
  • Ceftizoxime (Cefizox) (see Ceftizoxime, [[Ceftizoxime]])
  • Ceftriaxone (see Ceftriaxone, [[Ceftriaxone]])

Fourth Generation

  • Cefepime (Maxipime) (see Cefepime, [[Cefepime]])

Fifth Generation

  • Ceftaroline (Teflaro, Zinfloro) (see Ceftaroline, [[Ceftaroline]])
  • Ceftobiprole (Zeftera, Zevtera) (see Ceftobiprole, [[Ceftobiprole]])

Adverse Effects

Pulmonary Adverse Effects

  • Drug-Induced Pulmonary Eosinophilia (see Drug-Induced Pulmonary Eosinophilia, [[Drug-Induced Pulmonary Eosinophilia]])
    • Epidemiology: has been reported with Cephalexin and Cefotiam

Other Adverse Effects


References

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