β-Lactam Antibiotics


Agents

Penicillins (see Penicillins)

Natural Penicillins

  • Benzathine Penicillin
  • Penicillin G (Benzylpenicillin) (see Penicillin G)
  • Penicillin V
  • Procaine Penicillin

Penicillinase-Resistant Penicillins

Aminopenicillins

  • General Comments
    • Vulnerable to Inactivation by β-Lactamases
  • Amoxicillin (see Amoxicillin): due to potential inactivation by β-lactamases, usually used in a formulation with a β-lactamase inhibitor (like clavulanic acid)
  • Ampicillin (see Ampicillin): due to potential inactivation by β-lactamases, usually used in a formulation with a β-lactamase inhibitor (like sulbactam)
  • Bacampicillin

Extended-Spectrum/Anti-Pseudomonal Penicillins

  • General Comments
    • Have Activity Against Many Gram-Negative Organisms of the Enterobacteriaceae Family (Including Pseudomonas Aeruginosa)
    • Vulnerable to inactivation by β-lactamases
  • Acylaminopenicillins
    • Azlocillin
    • Mezlocillin
    • Piperacillin: due to potential inactivation by β-lactamases, usually used in a formulation with a β-lactamase inhibitor (like tazobactam)
  • Alpha-Carboxypenicillins
    • Carbenicillin
    • Ticarcillin: due to potential inactivation by β-lactamases, usually used in a formulation with a β-lactamase inhibitor (like clavulanic acid)

Cephalosporins (see Cephalosporins)

First Generation

Second Generation

Third Generation

Fourth Generation

Fifth Generation

Carbapenems (see Carbapenems)

Monobactams

  • Aztreonam (Azactam) (see Aztreonam)
    • Note that Aztreonam Has a Different Target within the Bacterial Cell Wall, as Compared to the Above β-Lactam Antibiotics

Adverse Effects

Allergic/Immunologic Adverse Effects

Angioedema (see Angioedema)


References