Anti-Fibrinolytics

Indications

Trauma (see Trauma-General, [[Trauma-General]]))

  • Clinical Efficacy
    • Systematic Review of Anti-Fibrinolytics in Acute Trauma (Cochrane Database Syst Rev, 2015) [MEDLINE]
      • Tranexamic Acid Decreased Mortality Rate in Trauma with Hemorrhage without Increasing the Risk of Adverse Effects
      • Tranexamic Acid Should Be GIven within 3 hrs of Injury: treatment later than 3 hrs is likely to be ineffective or harmful (data from CRASH-2 Trial, 2010) [MEDLINE]
      • Unclear if Tranexamic Acid Has Efficacy in Traumatic Brain Injury (TIB) (see Traumatic Brain Injury, [[Traumatic Brain Injury]])

Agents (Lysine Analogues)


References

  • Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010;376:23–32 [MEDLINE]
  • Antifibrinolytic drugs for acute traumatic injury. Cochrane Database Syst Rev. 2015 May 9;(5):CD004896. doi: 10.1002/14651858.CD004896.pub4. [MEDLINE]