Acyclovir (Zovirax)

Indications


Pharmacology

  • Anti-Viral

Administration

  • PO: xxx
  • IV: xxx

Dose Adjustment

  • Hepatic
  • Renal

Adverse Effects

Cardiovascular Adverse Effects

Dermatologic Adverse Effects

Gastroenterologic Adverse Effects

  • Elevated Liver Function Tests/Hepatitis (see xxxx, [[xxxx]])

Neurologic Adverse Effects (Neurotoxicity)

  • Time of Onset: usually develops early during course of treatment
  • Mechanism: probably related to high serum concentrations of acyclovir
  • Risk Factors for Neurotoxicity
    • Advanced Age
    • Bone Marrow Transplantation
    • Renal Failure
  • Neurologic Adverse Effects
    • Ataxia (see Ataxia, [[Ataxia]])
    • Coma (see Obtundation-Coma, [[Obtundation-Coma]])
    • Delirium (see Delirium, [[Delirium]])
    • Dizziness (see Dizziness, [[Dizziness]])
    • Focal Neurologic Signs (see Acute Motor Deficit, [[Acute Motor Deficit]])
    • Guillain-Barre Syndrome (see Guillain-Barre Syndrome, [[Guillain-Barre Syndrome]]): case report in at least one patient receiving acyclovir prophylaxis after allogeneic bone marrow transplant
    • Myoclonus (see Myoclonus, [[Myoclonus]])
    • Parasthesias (see Parasthesias, [[Parasthesias]])
    • Psychosis (see Psychosis, [[Psychosis]])
    • Seizures (see Seizures, [[Seizures]])

Renal Adverse Effects

  • Acute Kidney Injury (AKI) (see Acute Kidney Injury, [[Acute Kidney Injury]]): due to intratubular deposition and obstruction

Other Adverse Effects


References

  • xxx