Abiraterone (Zytiga)

Indications

  • Prostate Cancer (see Prostate Cancer, [[Prostate Cancer]])
    • In combination with prednisone, abiraterone is indicated to treat metastatic castration-resistant prostate cancer (mCRPC): co-administration with prednisone decreases the incidence and severity of adverse side effects

Contraindications

  • Liver Disease

Pharmacology

  • CYP17 Inhibitor: androgen biosynthesis inhibitor in prostate, tetes, and adrenal glands
    • Decreased serum testosterone and other androgens
    • Mineralocorticoid excess -> results in side efefcts of hypertension, hypokalemia, and fluid retention

Adverse Effects

Endocrine Adverse Effects

  • Adrenal Insufficiency (see Adrenal Insufficiency, [[Adrenal Insufficiency]])
    • Has been reported with discontinaution of concomitatnt prednisone and/or concurrent infection/stress

Cardiologic Adverse Effects

Renal Adverse Effects

  • Fluid Retention/Edema
  • Hypokalemia (see Hypokalemia, [[Hypokalemia]])

Gastroenterologic Adverse Effects

  • Hepatotoxicity: elevated transaminases and bilirubin

Other Adverse Effects (>10% incidence)

  • Fatigue
  • Cough
  • Joint Swelling
  • Hot Flush
  • Diarrhea
  • Vomiting
  • Dyspnea
  • Confusion
  • Urinary Tract Infection

References

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