Klebsiella Oxytoca

Microbiology

  • Member of Family Enterobacteriaceae (see Enterobacteriaceae, [[Enterobacteriaceae]])
    • Member of Klebsiella Genus (see Klebsiella, [[Klebsiella]])
  • Lactose-Fermenting Gram-Negative Rod

Carbapenem-Resistant Enterobacteriaceae (CRE)

  • Incidence: 2.93 cases/100k population [MEDLINE]
  • Organisms [MEDLINE]
    • Carbapenem-Resistant (Excluding Ertapenem)/Extended-Spectrum Cephalosporin-Resistant Escherichia Coli (see Escherichia Coli, [[Escherichia Coli]])
    • Carbapenem-Resistant (Excluding Ertapenem)/Extended-Spectrum Cephalosporin-Resistant Enterobacter Aerogenes (see Enterobacter Aerogenes, [[Enterobacter Aerogenes]])
    • Carbapenem-Resistant (Excluding Ertapenem)/Extended-Spectrum Cephalosporin-Resistant Enterobacter Cloacae Complex (see Enterobacter Cloacae, [[Enterobacter Cloacae]])
    • Carbapenem-Resistant (Excluding Ertapenem)/Extended-Spectrum Cephalosporin-Resistant Klebsiella Pneumoniae (see Klebsiella Pneumoniae, [[Klebsiella Pneumoniae]])
    • Carbapenem-Resistant (Excluding Ertapenem)/Extended-Spectrum Cephalosporin-Resistant Klebsiella Oxytoca (see Klebsiella Oxytoca, [[Klebsiella Oxytoca]])*
  • Clinical Associations
    • Most CRE’s were isolated from a urinary source
    • Most CRE’s were associated with high prevalence of prior hospitalizations, prior indwelling devices, or discharge to a long-term care setting

Clinical Manifestaions

Gastrointestinal Manifestations

  • Hemorrhagic Colitis: especially in patients treated with penicillin derivatives
    • Mechanism: production of a cytotoxin

Other Manifestations

  • xxx

Treatment

Acute Skin/Skin Structure Infection

  • Ceftaroline (Teflaro, Zinfloro) (see Ceftaroline, [[Ceftaroline]])

Community-Acquired Pneumonia (CAP)

  • Ceftaroline (Teflaro, Zinfloro) (see Ceftaroline, [[Ceftaroline]])

References

  • Epidemiology of Carbapenem-Resistant Enterobacteriaceae in 7 US Communities, 2012-2013. JAMA. 2015 Oct 5:1479-1487. doi: 10.1001/jama.2015.12480 [MEDLINE]