Fever

Etiology

Infection

Gastrointestinal

Hematologic/Immunologic

Neoplasm

Neurologic

Otolaryngologic

Pulmonary

Renal

Rheumatologic

Drugs

Intoxication

Withdrawal

Other


Physiology

  • Fever May Potentiate Neurologic Injury
    • The assumption that “central fever” due to central nervous system injury can be observed is less tenable

Clinical Manifestations

Other Manifestations

  • Fever

Treatment

Anti-Pyretics

Acetaminophen (Tylenol) (see Acetaminophen, Acetaminophen)

  • Clinical Efficacy
    • Study of Early Administration of Acetaminophen for Fever Due to Suspected Infection in the ICU (NEJM, 2015)* [MEDLINE]: early acetaminophen administration to treat fever due to probable infection did not impact the number of ICU-free days (through day 28)

Ibuprofen (Motrin) (see Ibuprofen, Ibuprofen)

  • Clinical Efficacy
    • xxxx

Surface Cooling

  • Indications: may be indicated in those who do not respond to anti-pyretics

Intravascular Cooling

  • Indications: may be indicated in those who do not respond to anti-pyretics

References

  • Hyperthermia and fever control in brain injury. Crit Care Med 2009;37(7):S250-57 [MEDLINE]
  • Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. NEJM 2015 vol. 373(23) pp. 2215-24 [MEDLINE]