Tissue Plasminogen Activator (tPA)
Indications
Pharmacology
Administration
- IV Infusion: 100 mg over 2 hrs
- Bolus Dose (During Code Blue): 0.6 mg/kg over 2 min
- Catheter-Directed Infusion: 50 mg over 2 hrs through peripheral IV or through PA catheter
Subsequent Heparin Administration
- Start heparin drip without bolus when PTT decreases to <2x upper limit of PTT normal range
- If PTT is >2x, repeat PTT q4 hrs until decreases to <2x upper limit of PTT normal range
Adverse Effects
References