Indications

Acute Bacterial Rhinosinusitis (see Acute Rhinosinusitis)

• xxxx

Bacillus Anthracis (Inhalational Anthrax) (see Anthrax)

Comments

• Doxycycline is One of First-Line Agents for Inhalational Anthrax Usually in Combination with a Second Agent (Infectious Diseases Society of America, IDSA/American Thoracic Society, ATS 2007 Consensus Guidelines for the Management of CAP) (Clin Infect Dis, 2007) [MEDLINE]

Community-Acquired Pneumonia (CAP) (see Pneumonia)

Clinical Efficacy (for the Treatment of Methicillin-Resistant Staphylococcus Aureus)

• There are Limited Data to Support the Use of Trimethoprim-Sulfamethoxazole, Clindamycin, Doxycycline/Minocycline in the Treatment of MRSA Community-Acquired Pneumonia (Ann Pharmacother, 2019) [MEDLINE]
  • Randomized Controlled trials are Required to Determine the Effectiveness of these Antibiotics in MRSA Community-Acquired Pneumonia
  • Clinicians Should Base Their Decision to Use These Agents on a Case-by-Case Basis Depending on Clinical Status and Susceptibility Results

XXXXXXXXX (Infectious Diseases Society of America, IDSA/American Thoracic Society, ATS 2007 Consensus Guidelines for the Management of CAP) (Clin Infect Dis, 2007) [MEDLINE]

Malaria (see Malaria)

Comments

• Doxycycline is Used in Combination with Quinine in the Treatment of Malaria (see Quinine)

Tularemia (see Tularemia)

Recommendations

• Doxycycline is the First-Line Agent for Pneumonic Tularemia (Infectious Diseases Society of America, IDSA/American Thoracic Society, ATS 2007 Consensus Guidelines for the Management of CAP) (Clin Infect Dis, 2007) [MEDLINE]

Urethritis (see Urethritis)

Regimens for Urethritis (Combined Regimen for Both Gonococcal and Chlamydial Urethritis) (see Urethritis)

• Azithromycin (1 g PO x 1) + Ceftriaxone IV (250 mg IM x 1) (see Azithromycin)
• Doxycycline (100 mg BID x 7 days) + Ceftriaxone IV (250 mg IM x 1) (see Ceftriaxone)

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Pharmacology

Tetracycline Antibiotic (see Tetracyclines)

• xxx

Metabolism

• xxx

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Administration

• PO: xxx
• IV: xxx

Dose Adjustment

• Hepatic:
• Renal:

Use in Pregnancy (see Pregnancy)

• xxxx

Use During Breast Feeding

• xxxx

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Adverse Effects

Gastrointestinal Adverse Effects

Acute Pancreatitis (see Acute Pancreatitis)

• Epidemiology
  • Definite Association with Acute Pancreatitis

Renal Adverse Effects

Acute Interstitial Nephritis (see Acute Interstitial Nephritis)

• Physiology
  • Class effect common to all tetracyclines

Other Adverse Effects

• xxx
• xxx
• xxx

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References

Indications

Community-Acquired Pneumonia (CAP) (see xxxx)

• Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults. Clin Infect Dis. 2007 Mar 1;44 Suppl 2:S27-72 [MEDLINE]
• What Is the Evidence for Co-trimoxazole, Clindamycin, Doxycycline, and Minocycline in the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Pneumonia?. Ann Pharmacother. 2019 Nov;53(11):1153-1161. doi: 10.1177/1060028019856721 [MEDLINE]