Desmopressin (DDAVP, DesmoMelt, Minirin, Minirin Melt, Octim, Stimate)


Indications

Diabetes Insipidus (DI) (see Diabetes Insipidus)

Hemophilia A (see Hemophilia A)

Management of “Autocorrection” During the Treatment of Hyponatremia (see Hyponatremia)

Platelet Dysfunction Following Cardiopulmonary Bypass (see Cardiopulmonary Bypass)

Primary Nocturnal Enuresis

Uremic Platelet Dysfunction (see xxxx)

Von Willebrand Disease (see Von Willebrand Disease)


Contraindications


Pharmacology

Desmopressin (DDAVP = 1-Deamino-8-D-Arginine Vasopressin) is a Synthetic analogue of Human 8-Arginine Vasopressin (i.e. Antidiuretic Hormone, ADH)

Structure

Effects of Desmopressin on Renal Collecting Duct V2 Receptors

Effects of Desmopressin on Endothelial Cell V2 Receptors

Effects of Desmopressin on Vasoconstriction/Blood Pressure and the Uterus

Metabolism


Administration

Intravenous Treatment of Uremic Platelet Dysfunction (see xxxx): 0.3 μg/kg

Intravenous Management of “Autocorrection” During the Treatment of Hyponatremia (see Hyponatremia)

Dose Adjustment

Use in Pregnancy (see Pregnancy)

Use During Lactation


Adverse Effects

Cardiovascular Adverse Effects

Dermatologic Adverse Effects

Neurologic Adverse Effects

Renal Adverse Effects


References