Atracurium


Indications


Pharmacology

Metabolism

-Metabolism: non-enzymatic Hoffman rxn + ester hydrolysis in plasma (does not depend on renal or hepatic metabolism)
– Burn patients may show resistance to NMJ blockers


Administration

Dose Adjustment

Drug Interactions

-Drug Interactions (all enhance Atra effect): lithium, aminoglycosides, polymyxins, magnesium, quinidine, procainamide


Adverse Effects

*Absence of Vagolytic Effect
*May Cause Histamine Release -> Bronchospasm/Hypotension

-SE: histamine release (hypotension, wheezing)/minimal ganglionic block/prolonged NMJ block (rare)
– No reports of vagal block tachycardia

Other Adverse Effects


References