Nickel Carbonyl

Exposure

  • Nickel Refining
  • Metal Recycling/Reclamation
  • Use of Nickel Carbonyl as Catalyst or Intermediate

Physiology

  • High-Intensity Inhalation of Nickel Carbonyl Fumes: exposure is common since nickel carbonyl fume is not acutely irritating
    • Usually associated with poor ventilation
    • Inhibition of enzymatic and pneumocyte functions
  • Note: inorganic nickel, by itself, is a sensitizer, but is not associated with pneumonitis

Clinical Presentations

(onset of symptoms usually 12-24 hrs after exposure)

  • Acute Pneumonitis (see Pneumonia, [[Pneumonia]])
  • Fever (see Fever, [[Fever]])
    • May occur
    • Not considered a type of metal fume fever
  • Pulmonary Infiltrates with Eosinophilia (see [[Pulmonary Infiltrates with Eosinophilia]])
  • Acute Lung Injury-ARDS (see Acute Lung Injury-ARDS, [[Acute Lung Injury-ARDS]])

Treatment

  • Dithiocarb (Diethyldithiocarbamate): use as a chelating agent is supported by animal studies in nickel carbonyl fume inhalation
  • Disulfiram: weaker support for its use in nickel carbonyl fume inhalation

References

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