Methyl Isothiocyanate

Epidemiology

  • Mass exposure with industrial accidents have been reported

Etiology

  • Breakdown Product of Soil Fumigant, Metam Sodium: used agriculturally
  • Although methyl isothiocyanate is a component of cigarette smoke, its link to disease is unclear

Physiology

  • Methyl Isothiocyanate Inhalation
    • Respiratory Irritant: no cyanide-mediated mechanism is involved

Clinical

  • Cough (see Cough, [[Cough]])
  • Acute Lung Injury-ARDS (see Acute Lung Injury-ARDS, [[Acute Lung Injury-ARDS]])
    • Pathology: diffuse alveolar damage

Treatment

  • Steroids: may be benficial in acute lung injury, but are unproven

References

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