Grapefruit

Pharmacology

  • Contains Bergamottin
    • Moderate Cytochrome P450 3A4 (CYP3A4) Inhibitor
      • Impacts Metabolism of Medications Which Require CYP3A4 for Metabolism

Adverse Effects

Cardiovascular Adverse Effects

  • QT Prolongation (see Torsade, [[Torsade]]): flavonoids in juice inhibit CYP3A4 (slowing metabolism of other medications) and directly inhibit the IKr channel -> QT prolongation

Pharmacologic Adverse Effects

Altered Metabolism of Certain Medications

  • xxxx

Other Adverse Effects

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References

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