Contaminated Rapeseed Oil

Epidemiology

  • 1981 outbreak in Spain

Physiology

  • Pulmonary hypertension due to ingestion of rapeseed oil contaminated by aniline/acetanilide dyes

Diagnosis

  • Open Lung Biopsy: medial hypertrophy, intimal proliferation of small pulmonary arteries: early signs of plexogenic arteriopathy
  • Resembles pulmonary veno-occlusive disease (except involves arteries + veins)

Clinical


References

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