Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE)

Epidemiology

  • Mean Age of Onset: 70-80 y/o
  • Sex: M>F with 2:1 Ratio

Etiology

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Physiology

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Diagnosis

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Clinical-Diagnostic Criteria

  • Age >50
  • Rheumatoid Factor (RF)-Negative
  • Sudden Onset
  • Pitting Edema of Hands

Clinical Manifestations

Rheumatologic Manifestations

Symmetric Polyarthritis and Synovitis (see Arthritis, [[Arthritis]])

  • Involved Joints
    • Ankles
    • Elbows
    • Knees
    • Metacarpophalangeal Joints
    • Proximal Interphalangeal joints
    • Shoulders
    • Wrists
  • Acute Pitting Edema of Back of Hands/Feet (see Peripheral Edema, [[Peripheral Edema]])

Other Manifestations

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Treatment

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References

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