Primary Pulmonary Waldenstrom’s Macroglobulinemia

Epidemiology

  • Extremely rare

Physiology

  • Primary involvement of lung by Waldenstrom Macroglobulinemia

Diagnosis

  • CXR/Chest CT Pattern:
    1) Parenchymal mass/ nodule: usually poorly circumscribed
    2) Pleural effusion:

Bone X-rays: diffuse osteopenia

BM Bx: positive in vast majority of cases


Clinical

Symptoms/ signs (usually asymptomatic)
-Dyspnea: may occur in cases with pleural effusion
-Other: fatigue/ bone pain/ fever/ weight loss/ lymphad-enopathy/ hepatosplenomegaly/ hyperviscosity syndrome

Complications:


Treatment

  • Treatment of pleural effusion