Epidemiology

• Extremely rare

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Physiology

• Primary plasmacytoma in lung
• Lung plasmacytoma may precede onset of overt Multiple Myeloma

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Diagnosis

• CXR/Chest CT Pattern:
  1) Parenchymal mass/ nodule: usually poorly circumscribed
  2) Pleural effusion:

Skeletal X-ray survey: diffuse osteopenia/ lytic bone lesions

BM Bx: positive in vast majority of cases

SPEP/ UPEP/ IEP: necessary to document monoclonal gammopathy

Bone FNA: may be useful for diagnosis
-Immunohistochemical stains: positive for monoclonal surface immunoglobulin

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Clinical

(usually asymptomatic)

• Dyspnea: may occur in cases with pleural effusion
• Other: fatigue/ bone pain/ fever/ weight loss

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Treatment

• True solitary plasmacytoma: treated with surgical excision or XRT
• Treatment of pleural effusion

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Prognosis

• Good for true solitary pulmonary plasmacytoma

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