Primary Pulmonary Melanoma

Epidemiology

  • Only 20 verified reported cases (all occurred in adults)

Physiology

  • Primary melanoma in lung (may possibly develop from neuroendocrine cells in lung)

Diagnosis

  • FOB: TBB/EBB is usually diagnostic
    -Immunohistochemical stains/ EM: useful to confirm diagnosis

CXR/Chest CT: all cases presented with both endobronchial disease and parenchymal masses v


Clinical

  • Melanoma originating from an extrapulmonary site (ocular/ cutaneous) site must be excluded

Treatment

  • Surgical resection: may produce prolonged remission
  • XRT: for non-surgical candidates
  • Immunotherapy: (IL-2, etc.) useful for refractory or recurrent disease

References

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