Multiple Laryngeal Papillomatosis

Epidemiology

  • Occurs only in patients with a history of childhood laryngeal papillomatosis (a viral disease of upper airway)

Physiology

  • Spread from upper airway to tracheobronchial tree in later years
  • Benign lung neoplasm

Diagnosis

  • FOB: sessile or stalked multiple papillary growths (lined with flattened squamous epithelium)
    • EBB: diagnostic
  • CXR: ateclectasis/post-obstructive pneumonia/ multiple nodular lesions (often cavitated)

Clinical Presentations

  • Hemoptysis:
  • Asthmatic wheezing:
  • Symptoms of Obstruction (see [[Obstructive Lung Disease]]
  • Lung Nodules (see [[Lung Nodule or Mass]])
  • Malignant transformation of nodule

Treatment

  • Surgery: resection is indicated where possible
  • Interferon therapy: has been used, but neither curative or of long-term benefit

References

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