Desquamative Interstitial Pneumonia (DIP)

Epidemiology

  • Mean Age of Onset: 40’s
  • Relationship to Smoking: most cases are smokers

Etiology

  • Tobacco Abuse
  • Connective Tissue Disease
  • Eosinophilic Granuloma
  • Asbestosis
  • Gauchers Disease
  • Niemann-Pick Disease
  • Hermansky-Pudlak Syndrome
  • Drugs
    • Amiodarone (see [[Amiodarone]])
    • Busulfan (see [[Busulfan]])
    • Interferon Alpha (see [[Interferons]])
    • Nitrofurantoin (see [[Nitrofurantoin]])
    • Rituximab (see [[Anti-CD20 Therapy]])
    • Sirolimus (see [[Sirolimus]])
    • Sulfasalazine (see [[Sulfasalazine]])
  • Toxins
    • Aluminum (see [[Aluminum]])
    • Cobalt (see [[Cobalt]]): in combination with tungsten carbide, cobalt produces hard metal pneumoconiosis
  • Idiopathic Desquamative Interstitial Pneumonia

Clinical

  • Insidious onset

Treatment

  • Good response to steroids (27% 12-year mortality rate)

References

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