Serum Galactomannan

Indications

Diagnosis of Invasive Aspergillosis in High-Risk Patients (Hematologic Malignancy, Hematopoietic Stem Cell Transplant)

  • Recommendations (Infectious Diseases Society of America 2016 Practice Guidelines) (Clin Infect Dis, 2016) [MEDLINE]
    • Serum Galactomannan is Recommended as an Accurate Marker for the Diagnosis of Invasive Aspergillosis in Adult and Pediatric Patients in Specific Populations (Hematologic Malignancy, Hematopoietic Stem Cell Transplant) (Strong Recommendation, High-Quality Evidence)
    • Serum Galactomannan is Not Recommended for Routine Blood Screening in Patients Receiving Mold-Active Antifungal Therapy or Prophylaxis, But Can Be Applied to Bronchoscopy Specimens from Those Patients (Strong Recommendation, High-Quality Evidence)
    • Serum Galactomannan is Not Recommended for Screening in Solid Organ Transplants or Patients with Chronic Granulomatous Disease (Strong Recommendation, High-Quality Evidence)

References

  • Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016 Aug 15;63(4):e1-e60. doi: 10.1093/cid/ciw326. Epub 2016 Jun 29 [MEDLINE]