Deep Venous Thrombosis (DVT) Prophylaxis (see Deep Venous Thrombosis)

Clinical Efficacy-Use of Sequential Compression Devices (SCD’s) in Addition to Pharmacologic Deep Venous Thrombosis Prophylaxis (see Sequential Compression Device)

• Systematic Review and Meta-Analysis of the Use of Sequential Compression Devices (SCD’s) in Addition to Pharmacologic Deep Venous Thrombosis Prophylaxis in Hospitalized Adults (Crit Care Explor, 2022) [MEDLINE]: n = 8,796 (17 trials)
  • Intermittent Pneumatic Compression Device was Mostly Applied Tp to the Thigh and Pharmacological Thromboprophylaxis Consisted of Primarily Low-Molecular-Weight Heparin
  • Adjunctive Intermittent Pneumatic Compression was Associated with a Decreased Risk of Venous Thromboembolism (15 Trials, RR = 0.53; 95% CI: 0.35-0.81]) and Deep Venous Thrmbosis (14 Trials, RR = 0.52; 95% CI: 0.33-0.81), But Not Pulmonary Embolism (7 Trials, RR = 0.73; 95% CI: 0.32-1.68)
  • The Quality of Evidence was Graded as Low, Downgraded by Risk of Bias and Inconsistency
  • Moderate and Very Low Quality Evidence Respectively, Suggests that Adjunctive Intermittent Pneumatic Compression is Unlikely to Change the Risk of All-Cause Mortality or Adverse Events
  • Subgroup Analyses Indicate a More Evident Apparent Benefit in Industry-Funded Trials