Tissue Plasminogen Activator (tPA)

Indications


Pharmacology

  • Thrombolytic

Administration

  • IV Infusion: 100 mg over 2 hrs
  • Bolus Dose (During Code Blue): 0.6 mg/kg over 2 min
  • Catheter-Directed Infusion: 50 mg over 2 hrs through peripheral IV or through PA catheter

Subsequent Heparin Administration

  • Start heparin drip without bolus when PTT decreases to <2x upper limit of PTT normal range
    • If PTT is >2x, repeat PTT q4 hrs until decreases to <2x upper limit of PTT normal range

Adverse Effects

  • Hemorrhage
  • xxx

References

  • xxx