Sunitinib (Sutent)

Indications

  • Imatinib-Resistant Gastrointestinal Stromal Tumor (GIST)
  • Renal Cell Carcinoma (see Renal Cancer, [[Renal Cancer]])

Pharmacology

  • Tyrosine Kinase Inhibitor

Metabolism

  • xxx

Administration

  • xxxx

Dose Adjustment

  • Hepatic:
  • Renal:

Adverse Effects

Cardiovascular Adverse Effects

  • Congestive Heart Failure (CHF) (see xxxx, [[xxxx]])
    • Epidemiology
  • QT Prolongation without Definite Association with Torsade (see Torsade, [[Torsade]])
    • xxx
  • Pleural and Pericardial Effusion (see xxxx, [[xxxx]])
    • Epidemiology: case report

Dermatologic Adverse Effects

  • Chemotherapy-Induced Acral Erythema (Hand-Foot Syndrome, Palmar-Plantar Erythrodysesthesia) (see Chemotherapy-Induced Acral Erythema, [[Chemotherapy-Induced Acral Erythema]])

Gastrointestinal Adverse Effects

Neurologic Adverse Effects

Pulmonary Adverse Effects

  • Acute Pneumonitis (see Pneumonia, [[Pneumonia]])
    • Epidemiology
  • Diffuse Alveolar Hemorrhage (DAH) (see xxxx, [[xxxx]])
    • Epidemiology: case report
  • Interstitial Pneumonia (see Interstitial Lung Disease, [[Interstitial Lung Disease]])
    • Epidemiology
  • Pleural and Pericardial Effusion (see xxxx, [[xxxx]])
    • Epidemiology: case report

Other Adverse Effects

  • xxx
  • xxx
  • xxx

References

  • Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet. 2007 Dec 15;370(9604):2011-9 [MEDLINE]
  • Acute cardiac failure after sunitinib. Ann Oncol. 2008 Mar;19(3):597-9. doi: 10.1093/annonc/mdn019. Epub 2008 Feb 13 [MEDLINE]
  • Cardiotoxicity associated with the cancer therapeutic agent sunitinib malate. Ann Oncol. 2008 Sep;19(9):1613-8. doi: 10.1093/annonc/mdn168. Epub 2008 Apr 23 [MEDLINE]
  • Metastatic renal cell carcinoma complicated with diffuse alveolar hemorrhage: a rare adverse effect of sunitinib. Int J Clin Oncol. 2010 Dec;15(6):638-41. doi: 10.1007/s10147-010-0104-3. Epub 2010 Jul 3 [MEDLINE]
  • Targeted therapies: Risk of heart failure with sunitinib. Nat Rev Clin Oncol. 2011 Aug 16;8(10):569. doi: 10.1038/nrclinonc.2011.129 [MEDLINE]
  • Lung toxicity in a patient treated with sunitinib. Eur Respir J. 2012 Nov;40(5):1300-3. doi: 10.1183/09031936.00048212 [MEDLINE]
  • Sunitinib-related interstitial pneumonia after treatment with temsirolimus: a case of possible recall phenomenon. Int J Urol. 2014 Apr;21(4):420-1. doi: 10.1111/iju.12332. Epub 2013 Oct 29 [MEDLINE]
  • Interstitial lung disease during targeted therapy in metastatic renal cell carcinoma: a case series from three centres. Med Oncol. 2014 Sep;31(9):147. doi: 10.1007/s12032-014-0147-9. Epub 2014 Aug 15 [MEDLINE]
  • Intolerance to sunitinib treatment in hemodialysis patients with metastatic renal cell carcinoma. Korean J Urol. 2014 Jan;55(1):74-6. doi: 10.4111/kju.2014.55.1.74. Epub 2014 Jan 15 [MEDLINE]
  • Pleural and pericardial effusions combined with ascites in a patient with severe sunitinib-induced hypothyroidism. Acta Clin Belg. 2016 Jun;71(3):175-7. doi: 10.1179/2295333715Y.0000000065. Epub 2016 Feb 7 [MEDLINE]