Sufentanil (Sufenta)

Indications

  • xxx

Pharmacology

  • Opiates (see Opiates, [[Opiates]])

Metabolism

  • xxxx

Administration

  • xxxx

Dose Adjustment

  • Hepatic:
  • Renal:

Adverse Effects

Neurologic Adverse Effects

Tonic Muscle Rigidity [MEDLINE]

  • Epidemiology: may also been seen with fentanyl, alfentanil, and morphine
  • Clinical: may involve chest and abdominal wall
    • Decreased Compliance/Increased Peak Inspiratory Pressures (PIP) on Mechanical Ventilation (see Ventilator Troubleshooting, [[Ventilator Troubleshooting]])
  • Treatment
    • Naloxone (Narcan) (see Naloxone, [[Naloxone]]): may be used in cases where reversal of the effect of the opiate would not be detrimental
    • Pharmacologic Paralysis: may be required in cases where reversal of the effect of the opiate would be deterimental

Other Adverse Effects

  • xxx
  • xxx
  • xxx

References

  • Postoperative myoclonus and rigidity after anesthesia with opioids.  Anesth Analg 1994; 78:783-786 [MEDLINE]