Sitagliptin (Januvia)

Indications

  • Non-Insulin Dependent Diabetes Mellitus (DM) (see Diabetes Mellitus, [[Diabetes Mellitus]])

Pharmacology

Metabolism

  • xxxx

Administration

  • PO: xxx

Dose Adjustment

  • Hepatic:
  • Renal:

Adverse Effects

Allergic/Immunologic Adverse Effects

Angioedema (see Urticaria-Angioedema, [[Urticaria-Angioedema]])

  • Epidemiology: possibly increased risk of angioedema when used in combination with angiotensin converting enzyme (ACE) inhibitors (see Angiotensin Converting Enzyme Inhibitors, [[Angiotensin Converting Enzyme Inhibitors]])
  • Pharmacology
    • DPP-4 plays a significant role in the degradation of bradykinin once ACE activity is reduced
    • DPP-4 primarily degrades substance P at its amino terminus when ACE is inhibited -> this kinin likely facilitates the occurrence of angioedema by the activation of neurokinin receptor 1

Other Adverse Effects

  • xxx
  • xxx
  • xxx

References

  • Angioedema induced by cardiovascular drugs: new players join old friends. Allergy. 2015 Oct;70(10):1196-200. doi: 10.1111/all.12680. Epub 2015 Jul 15 [MEDLINE]