Scopolamine

Indications

“Death Rattle” in Dying Patient

  • Clinical Efficacy
    • Systematic Review of Interventions for Noisy Breathing in the Dying Patient (Cochrane Database Syst Rev, 2008) [MEDLINE]
      • No Intervention (Pharmacologic or Non-Pharmacologic) Had Any Efficacy in Treating Death Rattle
    • Systematic Review of Antimuscarinic Drugs in zTreating Death Rattle (J Pain Symptom Manage. 2014) [MEDLINE]
      • Antimuscarinic Drugs (Glycopyrrolate, Scopolamine) Had No Efficacy in Treating Death Rattle (see Glycopyrrolate, [[Glycopyrrolate]])

Pharmacology

  • xxx

Metabolism

  • xxxx

Administration

  • xxxx

Dose Adjustment

  • Hepatic:
  • Renal:

Adverse Effects

Toxicologic Adverse Effects

  • Bromism (see Bromide, [[Bromide]])
    • Mechanism: due to formulation as scopolamine hydrobromide

Other Adverse Effects

  • xxx
  • xxx
  • xxx

References

  • Interventions for noisy breathing in patients near death. Cochrane Database Syst Rev. 2008 Jan 23;(1):CD005177 [MEDLINE]
  • Prevalence, impact, and treatment of death rattle: a systemic review. J Pain Symptom Manage. 2014;47:105–122 [MEDLINE]