Propoxyphene (Darvon)

Epidemiology

  • Commonly used orally in suicide attempts
  • May also be crushed, dissolved, and abused in IV form

Pharmacology

  • Rapidly absorbed orally

Adverse Effects

  • Acute Hypoventilation (see Acute Hypoventilation)
    • Clinical: due to to rapid absorption, death can occur within 30 min after oral ingestion
    • Treatment: naloxone
  • Acute Lung Injury-ARDS (see Acute Lung Injury-ARDS)
    • Epidemiology: has been reported
    • Treatment: supportive
  • Talc/Foreign Body Granulomatosis (see Foreign Body Granulomatosis)
    • Epidemiology: when propoxyphene is injected IV

References

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