Posaconazole (Noxafil, Posanol)

Indications

  • Aspergillus (see Aspergillus, [[Aspergillus]])
  • Candida (see Candida, [[Candida]])
  • Zygomycetes (see Zygomycetes, [[Zygomycetes]] and Mucormycosis, [[Mucormycosis]])
    • Order: Mucorales
      • Absidia
      • Apophysomyces
      • Cunninghamella
      • Cokeromyces
      • Mortierella
      • Mucor
      • Rhizomucor
      • Rhizopus
      • Saksenaea
      • Syncephalastrum
    • Order: Entomophthorales
      • Basidiobolus
      • Conidiobolus

Pharmacology

  • Triazole Anti-Fungal
    -Inhibits lanosterol 14-alpha demethylase (more potently than itraconazole)-> inhibits synthesis of ergosterol -> this disrupts the packing of acyl chains in phospholipids, impairing fungal membrane-bound systems (ATPase, electron transport enzymes)
  • Metabolism: predominantly hepatic

Administration

  • xxxx
  • Hepatic Dose Adjustment:
  • Renal Dose Adjustment:

Adverse Effects

  • xxx

References

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