Phenoxybenzamine

Indications

Diaphoresis/Hypertension in the Setting of Pheochromocytoma (see Hypertension, [[Hypertension]] and Pheochromocytoma, [[Pheochromocytoma]])

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Pharmacology

Metabolism

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Administration

  • PO (Essential Hypertension): start 0.25-1 mg/kg/day, increase slowly to achieve blood pressure control
  • PO (Pheochromocytoma): start 10 mg PO BID, increase slowly every other day until blood pressure is controlled
    • Typical Dose: 20-40 mg BID-TID
    • Max Dose (Reported): 240 mg/day

Dose Adjustment

  • Hepatic: none
  • Renal: none (use with caution)

Drug Interaction

  • Drugs Which Stimulate Both α-Adrenergic and β-Adrenergic Receptors: concomitant use may precipitate the hypotensive effect of phenoxybenzamine

Use in Pregnancy (see Pregnancy, [[Pregnancy]])

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Use in Lactation

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Adverse Effects

Cardiovascular Adverse Effects

Gastrointestinal Adverse Effects

  • Gastrointestinal Irritation

Neurologic Adverse Effects

  • Drowsiness/Fatigue (see Fatigue, [[Fatigue]])

Ophthalmologic Adverse Effects

  • Miosis (see xxxx, [[xxxx]])

Otolaryngologic Adverse Effects

  • Nasal Congestion

Other Adverse Effects

  • Inhibited Ejaculation

References

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