Pexelizumab

Indications

  • Adjunct in Percutaneous Intervention for ST Elevation Myocardial Infarction (STEMI) (see Coronary Artery Disease, [[Coronary Artery Disease]])
    • APEX Trial (JAMA, 2007) [MEDLINE]: pexelizumab did not impact mortality rate (mortality rate was low in the trial)

Pharmacology

  • Humanized monoclonal antibody that binds the C5 component of complement

Metabolism

  • xxx

Administration

  • xxx

Dose Adjustment

  • Hepatic: xxx
  • Renal: xxx

Adverse Effects

Other Adverse Effects

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  • xxx
  • xxx
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References

  • Pexelizumab for acute ST-elevation myocardial infarction in patients undergoing primary percutaneous coronary intervention: a randomized controlled trial. JAMA. 2007 Jan 3;297(1):43-51 [MEDLINE]