Pentobarbital

Indications


Pharmacology

Metabolism

  • xx

Administration

  • Load: 10 mg/kg over 30 min, 5 mg/kg q1hr x 3 doses (J Neurosurg, 1988) [MEDLINE]
  • Maintenance: 1 mg/kg/hr (J Neurosurg, 1988) [MEDLINE]

Dose Adjustment

  • Hepatic
  • Renal

Adverse Effects

Dermatologic Adverse Effects

Neurologic Adverse Effects

  • Sedation

Pulmonary Adverse Effects


References

  • High-dose barbiturate control of elevated intracranial pressure in patients with severe head injury. J Neurosurg. 1988 Jul;69(1):15-23 [MEDLINE]
  • Sedation for critically ill adults with severe traumatic brain injury: a systematic review of randomized controlled trials. Crit Care Med. 2011;39:2743–2751 [MEDLINE]
  • Sedation in traumatic brain injury. Emerg Med Int. 2012; vol 2012; article ID 637171, pp 1–11 [MEDLINE]