Pemetrexed (Alimta)

Indications

  • Peritoneal Mesothelioma (see xxxx, [[xxxx]])
  • Pleural Mesothelioma (see Mesothelioma, [[Mesothelioma]]): FDA-approved in 2004
  • Non-Small Cell Lung Cancer (see Lung Cancer, [[Lung Cancer]]): FDA-approved in 2008
    • PARAMOUNT Trial

Pharmacology

  • Folate Anti-Metabolite: inhibition of enzymes used in purine/pyrimidine synthesis -> inhibits RNA/DNA synthesis
    • Inhibition Thymidylate Synthase
    • Inhibition of Dihydrofolate Reductase
    • inhibition of Glycinamide Ribonucleotide Formyltransferase

Metabolism

  • xxxx

Administration

  • xxx

Dose Adjustment

  • xxxx

Adverse Effects

Hematologic Adverse Effects

  • Megaloblastic Anemia (see Anemia, [[Anemia]])

Other Adverse Effects

  • xxx

References

  • xxx