Indications
Peptic Ulcer Disease (PUD) (see Peptic Ulcer Disease, [[Peptic Ulcer Disease]])
- Treatment
- Prophylaxis
Pharmacology
- Proton Pump Inhibitor (PPI) (see Proton Pump Inhibitors, [[Proton Pump Inhibitors]])
Metabolism
- xxx
Administration
- PO
- IV
Dose Adjustment
- Hepatic
- Renal
Drug Interactions
- Methotrexate (see Methotrexate, [[Methotrexate]])
- Proton Pump Inhibitors Impair Urinary Clearance of Methotrexate and Increase the Risk of Renal Toxicity: the mechanism is unclear -> proton pump inhibitors should be discontinued prior to methotrexate administration
Adverse Effects
Other Adverse Effects
- xxx
References
-
Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy. Br J Clin Pharmacol. 2009;67:44–49 [MEDLINE]
-
Delayed elimination of methotrexate associated with co-administration of proton pump inhibitors. Anticancer Res. 2010;30:3807–3810 [MEDLINE]
-
Accumulating evidence for a drug-drug interaction between methotrexate and proton pump inhibitors. The Oncologist. 2012;17:550–555 [MEDLINE]
-
Rational administration schedule for high-dose methotrexate in patients with primary central nervous system lymphoma. Leuk Lymphoma. 2012;53:1867–1875 [MEDLINE]