Oxybutynin (Ditropan)

Indications

  • xxx

Pharmacology

  • xxx

Metabolism

  • xxxx

Administration

  • xxxx

Dose Adjustment

  • Hepatic:
  • Renal:

Adverse Effects

Neurologic Adverse Effects

Increased Risk of Dementia (with Chronic Anti-Cholinergic Use)

  • Epidemiology: anticholinergic-induced cognitive impairment is generally considered reversible on discontinuation of anticholinergic therapy
    • However, studies suggest that anticholinergic agents may be associated with an increased risk for dementia
  • Prospective Cohort Study (JAMA Int Med, 2015) [MEDLINE]: higher cumulative anticholinergic use (most commonly tricyclic antidepressants, first-generation antihistamines, and bladder anti-muscarinics) was associated with an increased risk for dementia

Toxicologic Adverse Effects

Other Adverse Effects

  • xxx
  • xxx
  • xxx

References

  • Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study. JAMA Intern Med 2015;175:401-407 [MEDLINE]